A scientific review of research regarding the safety aspects of the use of refrigerant R1234yf in Mobile Air Conditioning (MAC) systems, published by the European Commission, concludes that there is no evidence of a serious risk in the use of this refrigerant in MAC systems under normal and foreseeable conditions of use.The review, carried out by Europe’s Joint Research Centre, provided an in-depth analysis of testing and a subsequent report on the refrigerant’s safety by KBA (Kraftfahrt Bundesamt, the German authority responsible for market surveillance and product safety for road vehicles) in order to ascertain whether the results stemming from the tests were well founded and supported by a rigorous and scientific methodology.